منابع مشابه
Viral oncogenes and cellular prototypes.
The structural hallmark of retroviral transforming onc genes is a specific RNA sequence that is unrelated to the essential retroviral genes but closely related to certain cellular prototypes termed proto-onc genes. Two types of onc genes have been distinguished. Type I are onc genes which utilize elements of specific sequences only to encode a transforming protein. Type I1 onc genes are hybrids...
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Prognosis in lung cancer, one of the commonest cancers in the developed world, is poor, with less than 13% of all lung cancer patients surviving more than 5 years after diagnosis. With such an elevated mortality rate, it is important to elucidate the genetic changes involved in the pathogenesis of lung cancer. The process of carcinogenesis can be divided into the three stages of initiation, pro...
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The activation of oncogenes and inactivation of tumor suppressor genes (TSGs) have been implicated in the development of many human and animal malignancies. Changes in certain specific genes have been shown to be of potential value for diagnosis and prognosis, as well as treatment, of some cancers. By contrast, no oncogene has been correlated conclusively at the DNA level with the initiation an...
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In recent decades we have been given insight into the process that transforms a normal cell into a malignant cancer cell. It has been recognised that malignant transformation occurs through successive mutations in specific cellular genes, leading to the activation of oncogenes and inactivation of tumor suppressor genes. The further study of these genes has generated much of its excitement from ...
متن کاملOncogenes at viral integration sites.
Most retroviruses are innocuous to the cells they infect and do not encode transforming genes, yet many are implicated in naturally occurring cancers that arise at high frequency in virus-infected animals. It is now clear that the oncogenic properties of these viruses can be attributed to the stochastic activation of cellular oncogenes by the insertion of proviral DNA. Specific cancers ensue fr...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1985
ISSN: 0014-5793
DOI: 10.1016/0014-5793(85)80089-2